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When ingestion bioavailability of ranitidine is about 50%. At a dose of 150 mg Cmax achieved within 2-3 hours after dosing and are 300-550 ng / ml.
When V / m, the introduction of ranitidine Cmax plasma levels achieved in the first 15 min after injection.
Distribution
Ranitidine crosses the placenta. Excreted in *** milk.
Metabolism
Partially biotransformed in the liver.
Withdrawal
Excretion mainly kidneys. T1 / 2 - 2-3 hours 93% of dose in / in the introduction and 60-70% after oral dose excreted in the urine, the remainder - with the ***.
Unchanged in the urine output 70% of the dose in / in the introduction, and 35% of the dose - after taking the drug inside.
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